French-Irish paper on cancer one of the most highly cited [fr]
A French-Irish paper on cancer is one of the most highly cited in the world. His authors are part of an old-established French-Irish collaboration.
The authors of one of the most highly cited on cancer published in the journal Cancer Discovery, the journal of the American Association for Cancer Research are Eric Chevet (INSERM, France) and Afshin Samali (CÚRAM, Ireland).
Long-time collaborators, their research focuse on the fields of cell stress and cell death, and the role played by the endoplasmic reticulum (ER) in the life/death decisions that a cell makes and the associated implications for human disease. ER is found in eukaryotic cells (cells which have their DNA enclosed in their nucleus) and constitutes an essential element of the internal membrane network and plays a crucial role in the protein folding process. Cellular stress responses are mechanisms activated by cells in response to stressful stimuli (extreme temperatures, exposure to toxins and mechanical damage).
The researchers are working on describing how the unfolded protein response controls cell death and survival, and how it is regulated and how cell stress responses influence humain disease.
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